Leaving Hobby Airport, follow the Interstate 45 (also known as US 75 or Gulf Freeway) North signs
or take Broadway to Interstate 45 and go north on 45

Stay in the left lanes on 45 and exit 610 West
Continue on 610 West to the Fannin exit (Astrodome exit)
Turn right (north) on Fannin
Turn left on Dryden
Turn left at Travis

The hotel address is:
6633 Travis Street, Houston, Texas, 77030-1308

See Houston area and Rice area maps below: