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Resume
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Summary
- Strong background in the application of multi-step synthetic methods used for the preparation of modified nucleic acids and other biologically active chemicals .
- Experience in conformational and dynamic studies of the modified RNAs, and their interactions with proteins .
- Experience in the determination of the RNA structures and their complexes with proteins and other RNA using NMR.
- Multiple awards for excellence in science and study
Education
2004
Completed advanced NMR course learning product operator formalism (BIOS 481- Molecular Biophysics) and practical X-ray crystallography course (BIOS 535).
2001
Ph.D., Organic Chemistry, Center of Molecular and Macromolecular Studies, Polish Academy of Sciences , Lodz (Poland).
Thesis title: Chemistry and Stereochemistry of Nucleosidyl Phosphorofluoridates and Their Structural Analogues. Advisor: Professor Jan Michalski.
1992
M. Sc. in the Organic Chemistry, Institute of the Organic Chemistry, Department of Pharmacy, Medical Academy , Lodz (Poland) .
Research Experience
2002 - to the present
Welch Postdoctoral Research Associate : Rice University, Department of Biochemistry and Cell Biology, Mentor: Dr . Edward P. Nikonowicz
Synthesized the modified RNAs and studied their structure, dynamics, and interactions with proteins.
Experienced in the expression and purification of the unlabeled and 13C,15N –labeled proteins in Escherichia coli.
Experienced in preparation of the 13C, 15N-labeled RNAs using enzymatic and chemical methods .
Applied the homonuclear and heteronuclear NMR techniques in conformational and dynamic studies of the complex RNA with proteins and other RNAs.
1993-2001
Senior Research Assistant: Center of Molecular and Macromolecular Studies of the Polish Academy of Sciences (Prof. Jan Michalski).
Synthesized and studied of the modified P-chiral dinucleotides .
1998/1999 (4 months)
Visiting Scientist : at Prof. Joachim W. Engel’s group, Institut für Organische Chemie, Universität Frankfurt, Frankfurt am Main, Germany
Studied the synthesis and reactivity of the new phosphitylating reagents containing P-F and P-CF3 bonds.
1995 (3 months)
Visiting Scientist : at Prof. Joachim W. Engel’s group , Institut für Organische Chemie, Universität Frankfurt, Frankfurt am Main, Germany
Studied the reactivity and stability of the P-F containing dinucleotides and their solid phase synthesis
Relevant Skills
- Protein expression and purification.
- Nucleic acid (RNA & DNA) chemical and enzymatic synthesis and purification.
- Experience in using Varian 500, 600 : 2D-NMR, 3D-NMR
- Fluorescence spectroscopy and UV-visible and spectrophotometry, Circular Dichroism Spectroscopy
- Electrophoresis and Chromatography
- Experience in using UNIX - based computer systems , SGI machines, PCs and Macs.
- Experience in Molecular dynamics and Molecular Modeling methods with XPLOR, XPLOR-NIH, HyperChem, Insight II
- Experience in using a variety of Molecular Viewers such as PyMol, Chimera, RasMol
- Proficient with NMRPipe, Sparky and Felix2000
Awards
2003
Travel award, Nucleic Acids Gordon Conference, Newport , RI .
Travel award, 39th International Union Pure and Applied Chemistry Congress, (IUPAC), Ottawa, Canada .
2002
IUPAC ( International Union of Pure and Applied Chemistry) Award for Young Chemist .
Sigma-Aldrich Award for Young Chemist, Polish Chemical Society .
1992
President’s Award for excellence in study, Poland
Teaching and guiding experience
2005 Teaching the BIOS122 course ( Fundamental Concepts in Biology), Rice University.
2002-present Guidance and supervision of undergraduate students, Rice University
1993-2001 Guidance and teaching of graduate students, Center of Molecular and
Macromolecular
Studies of the Polish Academy of Sciences, Poland
Publications 24
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