BioSciences Department

6100 Main Street

Houston, TX 77005

Antibacterial resistance is a great challenge to public health and contributes to a great number of deaths and infections. The microbial evolution studies in our lab on Gram-positive bacteria have shown that one of the main factors in the evolution of resistance to Tigecycline (an antibiotic of last resort) is the acquisition of deletions upstream of the gene that encodes TetM, a ribosomal protecting protein, which is also associated with horizontal gene transfer. In collaboration with Kathryn Beabout, I study the biochemical and biophysical factors of this resistance pathway.

Publications:

Nossoni, R.; Nosrati, M.; Wang, W.; Borhan, B.; Geiger, J. H. “Wavelength regulation of all-trans-retinal protein pigments by water molecules” (Manuscript in preparation).

Nosrati, M.; Berbasova, T.; Vasileiou, C.; Borhan, B.; Geiger, J. H. “ Photo isomerization of a rhodopsin mimic: spectroscopy and structural insights” (Manuscript ready for submission).

Berbasova, T.; Santos, E. M.; Nosrati, M.; Vasileiou, C.; Geiger, J. H.; Borhan, B. “Light Activated Reversible Imine Isomerization: Towards a Photochromic Protein Switch.” ChemBioChem. 2016, 17, 1-9.

Thornburg, C. K.; Wortas-Strom, S.; Nosrati, M.; Geiger, J. H.; Walker, K. D. “Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity.” Biochemistry. 2015, 54, 6230-6242.

Yapici, I.; Lee, K. S. S.; Berbasova, T.; Nosrati, M.; Jia, X.; Vasileiou, C.; Wang, W.; Geiger, J. H.; Borhan, B. “Turn On’ Protein Fluorescence: In-Situ Formation Of Cyanine Dyes” J. Am. Chem. Soc. 2015, 137, 1073-1080.

Nossoni, Z.; Assar, Z.; Yapici, I.; Nosrati, M.; Wang, W.; Vasileiou, C.; Borhan, B.; Geiger, J. H. “The Crystal Structures Of Holo-Wt human Cellular Retinol Binding Protein II (hCRBPII) Bound To Retinol And Retinal” Acta Crystallogr D. 2014, 70, 3226-3232.

Mahernia, S.; Adib, M.; Mahdavi, M.; Nosrati, M.  “A Solvent-Free Reaction Between Acetophenone Oximes And Epoxy Styrenes: An Efficient Synthesis Of 2,4,6-Triarylpyridines Under Neutral Conditions” Tetrahedron Lett. 2014, 55, 3844-3846.

Berbasova, T.; Nosrati, M.; Vasileiou, C.; Wang, W.; Lee, K. S. S.; Yapici, I.; Geiger, J. H.; Borhan, B. “Rational Design Of A Colorimetric pH Sensor From A Soluble Retinoic Acid Chaperone” J. Am. Chem. Soc. 2013, 135, 16111-16119.

Adib, M.; Fatemi, S.; Nosrati, M.; Bijanzadeh, R. H., “One-Pot Three-Component   Reaction    Between   2-Aminopyridines, Aldehydes And Meldrum’s Acid In Water: An Efficient Synthesis Of β-Amino Acids” Synlett.  2008, 20, 3177-3179.

Adib, M.; Sayahi, H. M.; Nosrati, M.; Zhu, L-G., “A Novel, One-Pot, Three-Component Synthesis Of 4H-Pyrido[1,2-A]Pyrimidines” Tetrahedron Lett. 2007, 48, 4195-4198.

Adib, M.; Nosrati, M.; Mahdavi, M.; Zhu, L-G.; Mirzaei, P. “A Novel, One-Pot, Three-Component Synthesis Of 5H-[1,3]Thiazolo[3,2-A]Pyrimidine Derivatives” Synlett. 2007, 17, 2703-2706.