Milya G. Davlieva, Ph.D.

Adenylate kinases are small enzymes that catalyze the interconversion of adenylate species (AMP, ADP, ATP), maintaining their homeostasis in the cell. AK’s from a variety of organisms provide a unique opportunity to study relations between functions, dynamics and protein stabilities. There are two oligomeric classes of AK: monomeric as found in Eubacteria and trimeric in Archaebacteria. I am studying monomeric Marinibacillus marinus AK, and trimeric AK from Methanococcus maripaludis, a mesophilic methanogenic Archaebacteria using a combination of; X-ray crystallography, circular dichroism and enzyme activity assays to gain a better understanding of the evolution of protein thermostability and activity differences in the AK family of enzymes.

Selected publications:
Strych U., Davlieva M., Longtin JP., Murphy EL., Im H., Benedik MJ., Krause KL. Purification and preliminary crystallization of alanine racemase from Streptococcus pneumoniae. BMC Microbiol. (2007),7(1);40.

Davlieva M.G., Lindeman S.V., Neretin I.S., Kochi J.K. Isolation, X-ray Structures, and Electronic Spectra of Reactive Intermediates in Friedel-Crafts Acylations. Journal of Organic Chemistry (2005), 70(10), 4013-4021.

Lindeman, S. V.; Neretin, I. S.; Davlieva, M. G.; Kochi, J. K. Isolation and X-ray Structures of Labile Benzoic-and Acetic-Acidium Carbocations. Journal of Organic Chemistry (2005), 70(8), 3263-3266.

Davlieva Milya G., Sergey V. Lindeman, Ivan S. Neretin and Jay K. Kochi. Structural effects of carbon monoxide coordination to carbon centers. r- and s- bindings in aliphatic acyl versus aromatic aroyl cations. New J. Chem. (2004), 28,1568-1574.

Davlieva, Milya G.; Lue, Jian-Ming; Lindeman, Sergey V.; Kochi, Jay K. Crystallographic Distinction between “Contact” and “Separated” Ion Pairs: Structural Effects on Electronic/ESR Spectra of Alkali-Metal Nitrobenzenides. Journal of the American Chemical Society (2004), 126(14), 4557-4565.