Anisha Perez |
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Graduate Student Ph.D. candidate Biochemistry and Cell Biology |
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Keck Hall, Room 327 |
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BioSciences Department 6100 Main Street Houston, TX 77005 Ph: 713-348-2492 |
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| Integral membrane drug effluxers are known to cause multidrug-resistance (MDR) in a wide variety of organisms. These transporters are difficult to characterize by traditional in vitro studies as they span one or both of the bacterial membranes. Our lab has developed a mathematical model that can predict the growth of a strain at a variety of selection conditions from kinetic properties. Most importantly, this relationship is reversible | |
| allowing us to predict kinetic properties from growth rates. This utility opens up a new avenue for the study of proteins which are challenging to characterize. My goal is to use an extended version of this model to include the tetracycline and minocycline drug effluxer tet(B) and predict its physicochemical properties from high throughput growth rate assays. | |
Publications Beabout K, Hammerstrom TG, Perez A, Magalhaes B, Prater A, Clements TP, Arias C, Saxer G, Shamoo Y. "The ribosomal S10 protein is a general target for decreased tigecycline susceptibility." Antimicrobial Agents and Chemotherapy. 2015 Jun 29. | |
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