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Reading for Circadian Rhythm Assignment
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Circadian Rhythms - review articles
Dunlap, J.C., 1999, Molecular bases for circadian clocks. Cell 96:271-290 (Highly recommended background reading) 
Young, M.W., 1998, The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. Annu. Rev. Biochem. 67:135-152.


Circadian Rhythms - Assigned papers (first paper due Nov. 6; comprehensive paper due Dec. 4)
Paper 1.  Hardin, P.E., Hall, J.C., Rosbash, M., 1990, Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.  Nature 343:536-540.
Paper 2.  Gekakis, N., et al., 1995, Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.  Science 270:811-815.
Paper 3.  Aronson, B.D., Johnson, K.A., Loros, J.J., and Dunlap, J.C., 1994, Negative feedback defining a circadian clock:  Autoregulation of the clock gene frequency.  Science 263:1578-1584.
Paper 4.  Froehlich, A.C., Liu, Y., Loros, J.J., and Dunlap, J.C., 2002, White Collar-1, a circadian blue light photoreceptor, binding to the frequency promoter.  Science 297:815-819.
Paper 5.  Vitaterna et al., 1994, Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.  Science 264:719-725.
Paper 6.  Gekakis, N., et al., 1998, Role of the CLOCK protein in the mammalian circadian mechanism.  Science 280:1564-1569.
Paper 7.  Toh, K., et al., 2001, An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.  Science 291:1040-1043.


Biochemistry