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Reading for Bartel lectures
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Sex Determination and Dosage Compensation - Drosophila (Oct. 9, 21)
Parkhurst and Meneely, 1994, Sex determination and dosage compensation: Lessons from flies and worms. Science 264:924-932
Bashaw and Baker, 1996, Dosage compensation and chromatin structure in Drosophila. Cur. Op. Gen. Dev. 6:496-501
Conrat, B. and Horvitz, H.R., 1999, The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell 98:317-327 (optional)
Sex Determination and Dosage Compensation - C. elegans (Oct. 28, 30)
Cline and Meyer, 1996, Vive la différence: Males vs females in flies and worms, Annu. Rev. Genet. 30:637-702
Meyer, 2000, Sex in the worm, counting and compensating X-chromosome dose, Trends in Genetics 16:247-253
Ryner et al., 1996, Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene, Cell 87:1079-1089 (optional)
Sex Determination and Dosage Compensation - mammals (Nov. 4)
Boumil RM, Lee JT., 2001, Forty years of decoding the silence in X-chromosome inactivation.  Hum Mol Genet. 10:2225-2232  (recommended)
Koopman P, Gubbay J, Vivian N, Goodfellow P, Lovell-Badge R., 1991, Male development of chromosomally female mice transgenic for Sry.  Nature 351:117-121 (optional)
Panning et al., 1997, X Chromosome inactivation is mediated by Xist stabilization, Cell 90:907 (optional)
Plath K, Mlynarczyk-Evans S, Nusinow DA, Panning B., 2002, Xist RNA and the mechanism of X chromosome inactivation. Annu Rev Genet. 36:233-278 (optional)


Drosophila Embryonic Pattern Formation (Nov. 6, 18, 20, 25)


Circadian Rhythms (Dec. 2, 4)
Dunlap, J.C., 1999, Molecular bases for circadian clocks. Cell 96:271-290 (Highly recommended background reading for writing assignment
Young, M.W., 1998, The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. Annu. Rev. Biochem. 67:135-152.
Glossop, N.R.J. et al., 1999, Interlocked feedback loops within the Drosophila circadian oscillator. Science 286:766-767.
Ceriana, M.F., et al., 1999, Light-dependent sequestration of TIMELESS by CRYTOCHROME. Science 285:553-556.
Kume, K., et al., 1999, mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193-205.
Van der Horst et al., 1999, Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 398:627-630.
Griffen, E.A., et al., 1999, Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science 286:768-771.



Biochemistry