D. GP56 (possibly assisted by gp57 and gp58) inhibits host cell division.
Expression of gene 56 in uninfected cells prevented cell division without affecting cell growth, DNA synthesis, or chromosome segregation. SPO1 infection inhibited cell division, and this inhibition was prevented by a 56- mutation.
We are collaborating with Drs. Bill Margolin and Daniel Haeusser of the UT Medical School Houston to analyzed the mechanisms by which gp56 inhibits cell division.