[Research Summary] [Research Details] [Relevant Publications]


1. Fujita, D. J., B. M. Ohlsson-Wilhelm, and E. P. Geiduschek. 1971. Transcription during bacteriophage SP01 development: Mutations affecting the program of viral transcription. J. Mol. Biol. 57: 301-317.

2. Gage, L. P., and E. P. Geiduschek. 1971. RNA synthesis during bacteriophage SP01 development: six classes of SP01 DNA. J. Mol. Biol. 57: 279-300.

3. Losick, R., and J. Pero. 1981. Cascades of sigma factors. Cell 25: 582-584.

4. Sampath, A., and C. R. Stewart. 2004. Roles of genes 44, 50, and 51 in regulating gene expression and host-takeover during infection of Bacillus subtilis by bacteriophage SP01. J. Bacteriol. 186:1785-1792. PMID: 14996809.

5. Stewart, C. R. 1993. SP01 and related bacteriophages. pp. 813-829 in A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.), Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics. American Society for Microbiology, Washington, D. C.

6. Stewart, C. R., I. Gaslightwala, K. Hinata, K. A. Krolikowski, D. S. Needleman, A. S-Y. Peng, et al. 1998. Genes and regulatory sites of the "host-takeover module" in the terminal redundancy of Bacillus subtilis bacteriophage SP01. Virology 246: 329-340. PMID: 94421168.

7. Talkington, C., and J. Pero. 1977. Restriction fragment analysis of the temporal program of bacteriophage SP01 transcription and its control by phage-modified RNA polymerases. Virology 83: 365-379.

8. Tintut, Y., C. Wong, Y. Jiang, M. Hsieh, and J. D. Gralla. 1994. RNA polymerase binding using a strongly acidic hydrophobic-repeat region of sigma54. Proc. Natl. Acad. Sci. USA 91: 2120-2124.

9. Wei, P., and C. R. Stewart. 1993. A cytotoxic early gene of Bacillus subtilis bacteriophage SP01. J. Bacteriol. 175: 7887-7900. PMID: 8253678.

10. Wei, P., and C. R. Stewart. 1995. Genes that protect against the host-killing activity of the E3 protein of B. subtilis bacteriophage SP01. J. Bacteriol. 177: 2933-2937. PMID: 7751311.

11. Stewart, C.R., Yip, T.K., Myles, B., Laughlin, L. Roles of genes 38, 39, and 40 in shutoff of host biosyntheses during infection of Bacillus subtilis by bacteriophage SPO1.  Virology, 392: 271-274. PMID 19665746.

12. Stewart, C.R., Casjens, S.R., Cresawn, S.G., Houtz, J.M., Smith, A.L., Ford, M.E., Peebles, C.L., Hatfull, G.F., Hendrix, R.W., Huang, W.M., Pedulla, M.I. The genome of Bacillus subtilis bacteriophage SPO1.  J. Mol. Biol., 388: 48-70. PMID: 19285085.

A. General Introduction to bacteriophage SPO1.

B. GP44, gp50, and gp51 regulate the shutoff of host biosyntheses indirectly, by regulating expression of the genes of the host-takeover module.

C. GP40 plays a direct role in shutoff of both host DNA and RNA synthesis, and gp38 and gp39 regulate both shutoffs, by direct participation in the shutoff processes.

D. GP56 (possibly assisted by gp57 and gp58) inhibits host cell division.

E. GP55-53 may inhibit host protein synthesis.

F. Antibiotic Activities of SPO1 Proteins.